GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2292096 | 1 | rs66769776 | chr1:200782904 | DDX59 | chr1:200610119-200639126:- | -0.28 | -4.16 | 3.79E-5 | Epilepsy |
| THCA | cis | rs2275426 | 1 | rs6677007 | chr1:46400590 | CCDC163P | chr1:45960581-45965646:- | -0.52 | -10.14 | 5.21E-22 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6677007 | chr1:46400590 | GPBP1L1 | chr1:46092978-46152302:- | 0.15 | 3.83 | 0.000146 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6677007 | chr1:46400590 | MMACHC | chr1:45965856-45976737:+ | -0.21 | -4.57 | 6.3E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs6677007 | chr1:46400590 | MUTYH | chr1:45794915-45806142:- | 0.3 | 8.13 | 3.66E-15 | Body mass index |
| THCA | cis | rs9371538 | 1 | rs66775662 | chr6:151876216 | C6orf97 | chr6:151815175-151942327:+ | 0.33 | 4.62 | 4.98E-6 | Bone mineral density (spine) |
| THCA | cis | rs13191362 | 1 | rs66789102 | chr6:163104432 | PACRG | chr6:163148164-163736523:+ | 0.52 | 7.28 | 1.37E-12 | Body mass index |
| THCA | cis | rs17030613 | 1 | rs6679 | chr1:113243048 | MOV10 | chr1:113217048-113243367:+ | 0.19 | 4.51 | 8.17E-6 | Diastolic blood pressure;Blood pressure |
| THCA | cis | rs17030613 | 1 | rs6679 | chr1:113243048 | ST7L | chr1:113066142-113162405:- | 0.65 | 10.15 | 4.9E-22 | Diastolic blood pressure;Blood pressure |
| THCA | cis | rs6679002 | 1 | rs6679002 | chr1:63199936 | DOCK7 | chr1:62920398-63153969:- | 0.1 | 4.05 | 5.92E-5 | Blood metabolite levels |
| THCA | cis | rs7551345 | 1 | rs6679005 | chr1:31865615 | ZCCHC17 | chr1:31769842-31837780:+ | -0.29 | -5.42 | 9.55E-8 | Schizophrenia |
| THCA | cis | rs6679073 | 1 | rs6679073 | chr1:205756484 | PM20D1 | chr1:205797154-205819245:- | -0.43 | -7.04 | 6.67E-12 | Prostate-specific antigen levels |
| THCA | cis | rs6684514 | 1 | rs6679145 | chr1:156256000 | BGLAP | chr1:156182784-156213112:+ | 0.23 | 5.32 | 1.63E-7 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs6679145 | chr1:156256000 | C1orf85 | chr1:156259882-156265449:- | -0.17 | -3.99 | 7.72E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THCA | cis | rs6684514 | 1 | rs6679145 | chr1:156256000 | CCT3 | chr1:156278752-156308195:- | -0.32 | -6.95 | 1.24E-11 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |